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Putting a Foldable Microscope to the Test in the Amazon
A couple of months ago, I received an interesting package in the mail. It looked like a standard manila envelope, but inside was a device that could quite possibly revolutionize the way we view the microscopic world. I’m referring to the Foldscope, an origami-based optical microscope that is small enough to fit inside your pocket. The real kicker: the entire cost of the instrument is less than one dollar.
The Foldscope has received some recent and well-deserved media attention (the lab’s publication on this device recently made it in the top 20 papers in PlosOne for 2014) but I hadn’t seen many videos on the Foldscope being put to the test in the field. It seemed like there was a lot of potential for this invention but I wondered how it would fare on one of my expeditions through a jungle searching for unknown species. So I decided to assemble my miniature paper microscopes and travel to one of the most remote places in the world, the rainforest of the Peruvian Amazon, to give them a go.
The Results
Long story short, this device is amazing. During my time in the Amazon rainforest, I was able to investigate tiny insects, mites, fungi, and plant cells from 140x to 480x magnification without requiring a large and expensive conventional microscope.
The cells from a flower petal were recorded by connecting a cell phone to the Foldscope.
Some of the diverse arthropod specimens could potentially be new to science, so it was really exciting to document images and videos of these organisms right there in the field by connecting my phone to the Foldscope.
An unknown species of mite was documented by connecting a cell phone to the Foldscope.
A spider is infected by a parasitic fungus known as Cordyceps. The circles show regions of the fungus viewed under the Foldscope.
In the video, I investigate bizarre structures on a plant, which are known as leaf galls. These are sometimes created by insects, but they usually have to be taken back to a lab and inspected in detail under a microscope. Lucky for me, I had the Foldscope in the field! It turns out these were in fact due to insect larvae, which burrowed into the leaf and tweaked the chemistry of the plant to produce galls. Even with macro photography, I couldn’t get much detail of the larva, but at 140x magnification, under the Foldscope, I was able to document the morphology of this unknown critter.
Top left, a leaf is covered in galls. Top right, a cross-section of a gall; notice the tiny insect larva living inside! Bottom, the larva was placed under the Foldscope and viewed on my cell phone. Pictures and videos were recorded in real-time out in the Amazon rainforest.
Suspecting that the galls were formed by some sort of wasp or fly, I later got in touch with a couple of Diptera (fly) experts, Morgan Jackson (@BioInFocus) and Dr. Stephen Gaimari, who helped identify the gall-forming culprits as a possible species of fly belonging to the family Cecidomyiidae.
Final Thoughts
The research team, led by Dr. Manu Prakash, seeks to “democratize science” by developing tools that are able to scale up to match problems in global health and science education – and I believe they are doing just that with the Foldscope. This device is cheap, easy to use, and broadly applicable whether you’re a curious young student, a medical professional in the field, or someone who is interested in the numerous tiny things that surround us. Until now, I’ve never had a device that made viewing and sharing the microcosmos so accessible.
A closer look at the moss covering a tree in the tropical rainforest.
Morphology of a neotropical pseudoscorpion – all images were taken in the field with the Foldscope!
A breakdown of the unit costs for Foldscope components in volumes of 10,000 units, not including assembly costs (Cybulski, Clements, & Prakash 2014). The total cost of the Foldscope ranges from {%_CONTENIDO_%}.58 to {%_CONTENIDO_%}.97.
By Aaron Pomerantz
You can follow Aaron for more updates on Twitter @AaronPomerantz and the Stanford University Researchers @PrakashLab
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Such a wonderful experience deep in a part of the Amazon, Tambopata NP. They really involve you with what is happening at the research centre with evening lectures. The meals are outstanding and the rooms are comfortable and I had the best sleep. Dino our guide was outstanding. The river trip to see the Macaw claylicks was a beautiful outing. We saw Capybaras along the river and it was very scenic. The staff are friendly and very engaging. As a tour operator who sends clients to AFRICA for safari, I was hugely satisfied. Thank you, gracious. Food & drinks: Good was simply delicious Read all


An amazing experience in the Peruvian jungle. the information about the centre was very accurate so I knew what to expect but was blown away by the experience and competence of my guide for the four nights, Juan Carlos Yatto. JC was looking for birds for me from the moment he collected me at the airport, so we saw birds on the drive and on the boat ride as well as on the excursions themselves. I was in Peru three weeks and JC was my best guide by far. Don't miss the clay licks for sure, and the tower is also well worth the climb. Food and people are wonderful and the research very interesting. Read all


Das Tambopata Research Center ist eine wunderbare Lodge im Nationalpark Tambopata. Die charmanten, miteinander verbundenen Aufenthaltsräume und Zimmer befinden sich auf hölzernen Stelzen. Bei den offenen Gemeinschaftsräumen gibt es gemütliche Sitzecken, eine wunderbare Hängemattenrelaxzone und einen herrlichen Restaurantbereich, wo zu jeder Zeit Tee, Kaffee und Wasser zur Verfügung stehen. Die stilvollen Zimmer verfügen über bequeme Betten mit Moskitonetz und moderne, saubere Duschbereiche. Die Research Center Lodge mit den Forschungseinrichtungen liegt inmitten des Regenwaldes umgeben von der reinen Natur mit der fantastischen Flora und Fauna, welche dort auch weiterhin erforscht und geschützt wird. Jeden Abend gibt es dazu sehr interessante Vorträge. Die Mitarbeiter sind sehr freundlich, offen und zuvorkommend. Die Buffets waren sehr köstlich und reichhaltig mit Gerichten aus der Region. Es wird großer Wert auf ökologische und nachhaltig umweltschonende Bewirtschaftung gelegt. Von der Lodge aus ist es möglich, mit ausgebildeten Guides in Gruppen von maximal 6 Personen verschiedene Exkursionen zu machen. Speziell Timo war ausgesprochen freundlich, auf unsere Sicherheit bedacht, ging auf die individuellen Interessen der einzelnen Personen ein und vermittelte uns in seiner kompetenten Art umfangreiches Wissen über die Pflanzen- und Tierwelt. Er hatte dabei die wunderbare Fähigkeit, versteckte Wildtiere zu entdecken, und verschaffte uns wunderschöne Momente, auch durch das mitgetragene Teleskop, wodurch wir der Tierwelt näher sein konnten. So sahen wir u.a. Brüllaffen, Kapuzineraffen und Spideraffen mit ihren Kindern, viele Vögel insbesondere Papageien wie z.B. Scharlach- und Gelbbauch-Aras sowie Wasserschweine und verschiedene Insekten. Wir können diese wunderbare Lodge absolut weiterempfehlen. Die herrliche Tier- und Pflanzenwelt in dem wunderbar erhaltenen und geschützten Regenwald des Amazonas war auf unserer Peru-Reise ein wirklich fantastisches Erlebnis! Read all


Rainforest Expeditions is a wonderful company and the Posadas Amazonas lodge is a beautiful location to spend your time in the Amazon. The staff are all incredibly kind, helpful, and knowledgeable. The tours were very fun and we saw lots of animals including River otters, monkeys, birds, and capybaras. We loved our guide Luis and all the people we met. The food was delicious and locally grown and there was never a dull moment. Would highly recommend! Read all


I went to Posada as part of a wider group trip, so did not pay for it directly. The lodge feels very far from anywhere and yet it feels incredibly safe. The rooms are open to nature, but nothing was ever damaged (use the safe boxes as advised, especially for food - not that you'll need any - the catering is excellent, with plenty of vegetarian options, and snacks are also provided between meals). There are flushing toilets, incredible shower facilities and the beds are very comfortable with mosquito nets placed at night by the staff. Drinking water vats are strategicvally placed throughout the lodge but you may have a long-ish walk to the common areas through corridors. Some parts of the corridors are open to the elements, but umbrellas are provided everywhere in case of rain. There is obviously no air conditioning, but this helps you acclimatise. The lodge is run by a family and others from the Infierno community, which gives the place a homely feel, with resident tour guides and a local geologist for citizen science projects. Massage services are available and there is a local shop for souvenirs and essentials like bug spray, clothing and torches. Tons of activities can be arranged, but it's also nice to relax in the hammocks and common areas and listen to the sounds of nature. While this hotel is not going to be for everyone, I had the most incredible time! Read all


The place to go if you want to see Macaws in the Peruvian rainforest. We stayed at the Tambopata Reaearch Centre (TRC) for three days and had Juan Carlos Yatto as our guide for the duration of our stay. We loved the mission of the TRC ie Macaw conservation and the link between Macaw nest site availability and the overall health of the rainforest. Juan Carlos Yatto (there is another JC at the research centre) was a fantastic guide and really made a difference to our experience at the TRC. His knowledge of the different species of wildlife and plants was amazing, his ability to spot things in the day or at night was phenomenal and he really made things accessible for our group. His English is excellent (including great humour when appropriate) and is a super guy. I really do recommend the TRC abd Juan Carlos Yatto as a guide. We saw an abundance of wildlife of all descriptions thanks to him and learned a huge amount without being overloaded. Read all


Two planes, a bus and a boat…that’s how we made it to TRC, and every minute was worth it. Tambopata is a jewel, from the moment you are greeted by the guide assigned to you (Juan Carlos Gonzales for us) to the last boat ride back to civilization. Juan Carlos was amazing…on just one hike he found five of the seven species of monkeys in the area! He is truly an expert..can hear, see and even SMELL animals, birds and insects to point out to us. We upgraded to a deluxe suite and it was decadent! An elegant outdoor tub and shower on a private balcony was soo nice’ Although we went in the rainy season, it never rained while on a hike or excursion. It rained for a few minutes on our late afternoon cruise , but not enough to dampen our enthusiasm, or prevent us from seeing a capybara in the mid! (And despite the warning of a lot of mosquitoes, I have been bitten more in my own back yard!) The bar is great, there’s PLENTY of food…we are going home feeling so lucky to have had such a great connection to the beauty of the Amazon. Read all


We had a fantastic time for our 3N/4D stay at Tambopata Research Center. The whole experience was marvellous. Rooms and facilities were great and meals superb. The Staff, ably led by Tanya the manager, were all friendly and helpful. This is the only lodge actually inside the Tambopata National Park, and we enjoyed being so "remote". I like that you have one guide who coordinates and takes you on all your activities; Jair our guide was amazing. One morning our planned activity was rained out, and I liked that they have alternative "wet weather" activities planned. There are lectures each night by researchers, which were very interesting. Also citizen science projects that you can participate in. All up, it was a fantastic way to experience the Peruvian Amazon. Read all


Posada Amazonas by Rainforest Expeditions is an extraordinary place. From your arrival at the airport in Puerto Maldonado all the staff is always attentive to your needs. You travel by boat to the hotel Posada Amazonas and it is a unique experience. It really is a total disconnection and a recollection with Mother Nature 🌎 The buffet lunch is delicious (already included in the price). You have a guide who speaks Spanish and English at all times and accompanies you to explore the jungle, the river and other activities. The price is worth it. Outside my room I caught a glimpse of monkeys :) The night sky is starry and very spectacular ✨️ 5 star service. I will definitely come back. Read all


I stayed with my parents at Refugio Amazonas for 3 days. We really enjoyed our stay and had a wonderful time here. The staff were extremely kind and well informed. The lodge manager- Arturo in particular was very helpful. To highlight their culture: They prepared special vegetarian meals for my parents, always ensured we felt comfortable and all our needs were met. A stay here is a must do to get a real feel of the Amazon rainforest on your trip to Peru! Noteworthy details: There are a lot of activities for kids and families to do, but my personal favourites are: Macaw Claylick, OxBow river ride, sunset cruise and the canopy tower. Read all


I can't express how amazing our guides were. Incredibly knowledgeable and able to spot birds, frogs, spiders, animals, etc. with an almost unbelievable ability. The research and contributions to the jungle they are making at the Center are to be commended. The facilities were nice and kept clean and the staff was great, but between the walls in the rooms being open to the jungle, the heat, the bugs, underpowered fans, having to completely cover up for hikes due to bugs and then getting overheated, etc. it made for a tough stay. The food was good but after a couple days became repetitive. I would recommend this for serious birders who are willing to endure a bit for an incredible adventure. Read all
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